Changes in the Plasma Level of Some Hydrolytic Enzymes during the Resorption of Strogen-induced Medullary Bone in Cocks

The biochemical mechanisms by which bone is resorbed are not fully understood. It is generally assumed, however, that the mineral matter is removed under the influence of locally-produced acids and that the organic matter is solubilized by enzymic mechanisms. Acid hydrolases of lysosomal origin have been implicated in the process of bone resorption in organ culture (V AES , 19 65), and it was considered that a study of the activity of some lysosomal enzymes in plasma during the resorption of oestrogen-induced medullary bone might provide in vivo evidence for or against the participation of these enzymes in the process of bone resorption, on the